What is Pre-Implantation Genetic Testing? Dr. Hrishikesh Pai


Do you have any genetic or medical condition? Are you scared of passing any genetic disorder to your child? Then pre-implanatation testing can help you screen genetic disorder 

In this article, Dr. Hrishikesh Pai, one of the best IVF doctor in Gurgaon will discuss PGT and its advantages for parents. Dr. Hrishikesh Pai is a pioneer in the field of Infertility and IVF since 1991. He presently is the Director of the Bloom IVF Group which runs eight IVF centres all over India including Lilavati Hospital in Mumbai and Fortis Hospitals in New Delhi, Gurugram, Faridabad, Mohali and Navi Mumbai

The article will give you an overall insight about Pre-implantation genetic testing. If you are a couple looking to deliver a healthy baby, then by the end of this article you’ll have an idea on the basics of how genetic testing and screening of an embryo is done.

Read on to know more. 

What is Pre-implantation Genetic Testing?

Preimplantation genetic testing (PGT) is a cutting-edge procedure used to identify genetic abnormalities in embryos created with in vitro fertilization (IVF).

The goal of PGT is to allow your physician to select embryos predicted to be free of a specific genetic condition or chromosome abnormalities for transfer. This test provides patients with an opportunity to reduce the chance of a genetic disease in their future children prior to pregnancy.

If you want to know the best hospital in India for PGT services then you can click here.

Below we’ll see the three types of PGT testing,  

Types of Pre-implantation genetic testing:

The types of pre-implnatation genetic testing includes,

Preimplantation genetic testing for aneuploidy (PGT-A)



PGT-A is a test that examines embryonic cells to see if the number of chromosomes is within the normal range. An embryo can have too few or too many chromosomes if sperm or egg cells divide unequally, says Dr. Hrishikesh Pai, one of the best IVF doctor in Lucknow.

Most people have 46 chromosomes because they inherit 23 chromosomes from each parent. Monosomy is a missing chromosome, and trisomy is an extra chromosome. If an embryo or a cell is missing a chromosome or has an extra one, it is called aneuploidy.

Living birth, Turner syndrome (trisomy 18), Patau syndrome, Down syndrome, sometimes known as trisomy 21 (an extra chromosome in normal pair #21), and trisomy of chromosomal pairings can occasionally develop from trisomy of chromosome pairs (trisomy 13). Turner syndrome, monosomy in which one of the X chromosomes is absent, is the only type of monosomy that a child can survive. According to the Centers for Disease Control and Prevention, 1 in 700 infants has down syndrome.

Aneuploidy is one of the greatest causes of failed implantation for pregnancy and miscarriage and a major cause of congenital disabilities in children.

Preimplantation genetic testing for a monogenic disease (PGT-m)


PGT-M examines the genome for particular gene mutations that one (or both) of the parents is known to contain. There is a higher chance that a child will be born with a genetic mutation if one or both parents have a family history of genetic illnesses.

A disorder involving a single specific gene is due to a mutation in the DNA sequence. This results in diseases such as cystic fibrosis and sickle cell anemia. It can also cause an inherited genetic mutation such as the BRCA1 and BRCA2 mutations that greatly increase a woman’s risk of breast cancer and ovarian cancer.

PGT-M includes testing embryos made through IVF and transferring only the unaffected embryos.



Patients with known chromosomal structural rearrangements, such as an inversion or translocation, have their embryos examined using PGT-SR.

 Patients who have known structural rearrangements are more likely to produce embryos with an insufficient number of chromosomes. Live birth is less likely to occur from the damaged embryos. Patients with these issues frequently experience recurrent miscarriages.

The Advantages of PGT

According to Dr. Hrishikesh Pai, one of the top IVF doctor in Lucknow discusses some of the advantages of PGT that includes,

Few pregnancies losses

Pregnancy requires a healthy embryo. If both parents pass on abnormal chromosomes to the embryo, it won’t survive.PGT examines and identifies the healthiest embryos and then implants them.

The goal of IVF in the past was to boost pregnancy rates by implanting many embryos, increasing your chances of success. However, that can also result in miscarriage, unsuccessful implantation, or multiple births, all of which carry a high risk of harm.

 This will give you a higher chance of pregnancy and lower the probability of miscarriages. 

Quicker success rates

Finding the healthiest embryos early on will also help you prevent failure transfers, which will lead to a successful pregnancy more quickly.

IVF with higher success rates has many advantages. The physical and psychological toll that IVF and infertility can have are two of the most obvious. The financial burden can be lessened, though, if you are aware of the viability of your embryos from the beginning, says Dr. Hrishikesh Pai, one of the best IVF doctor in Gurgaon.

Less uncertainty 

Pre- and post-embryo transfer uncertainty can be greatly reduced by PGS/PGD procedures.

Even if you learn that your embryos have genetic defects, knowing this information can still assist you in preventing experiencing a miscarriage or pregnancy loss in the future. Additionally, the data will enable our staff to decide the best course of action to put you back on the path to a successful pregnancy.

Also Read: What Is Breast Cancer And How To Cope With It Dr Garvit Chitkara.


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